Motif ID: NFY{A,B,C}.p2

Z-value: 5.225


Transcription factors associated with NFY{A,B,C}.p2:

Gene SymbolEntrez IDGene Name
NFYA 4800 nuclear transcription factor Y, alpha
NFYB 4801 nuclear transcription factor Y, beta
NFYC 4802 nuclear transcription factor Y, gamma

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NFYCchr1_+_411574280.721.2e-36Click!
NFYAchr6_+_41040713-0.321.2e-06Click!
NFYBchr12_-_1045318750.152.8e-02Click!


Activity profile for motif NFY{A,B,C}.p2.

activity profile for motif NFY{A,B,C}.p2


Sorted Z-values histogram for motif NFY{A,B,C}.p2

Sorted Z-values for motif NFY{A,B,C}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFY{A,B,C}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_+_91926109 194.367 NM_001827
CKS2
CDC28 protein kinase regulatory subunit 2
chr14_+_54863672 159.261 NM_001130851
NM_005192
CDKN3

cyclin-dependent kinase inhibitor 3

chr1_-_197115566 143.977 NM_001206846
NM_018136
ASPM

asp (abnormal spindle) homolog, microcephaly associated (Drosophila)

chr17_-_38574042 142.957 NM_001067
TOP2A
topoisomerase (DNA) II alpha 170kDa
chr4_-_174255454 139.247 NM_001130688
NM_002129
HMGB2

high mobility group box 2

chr2_+_10262853 129.632 NM_001034
RRM2
ribonucleotide reductase M2
chr1_-_153643456 127.508 ILF2
interleukin enhancer binding factor 2, 45kDa
chr1_-_153643433 116.836 ILF2
interleukin enhancer binding factor 2, 45kDa
chr1_-_153643417 115.330 ILF2
interleukin enhancer binding factor 2, 45kDa
chr5_+_68462948 113.383 CCNB1
cyclin B1
chr1_-_153643428 111.296 ILF2
interleukin enhancer binding factor 2, 45kDa
chr2_+_10262694 111.171 NM_001165931
RRM2
ribonucleotide reductase M2
chr19_-_55919324 109.834 NM_014501
UBE2S
ubiquitin-conjugating enzyme E2S
chr20_+_47662782 108.484 NM_001316
CSE1L
CSE1 chromosome segregation 1-like (yeast)
chr5_+_177631496 106.039 NM_004499
NM_031266
HNRNPAB

heterogeneous nuclear ribonucleoprotein A/B

chr5_+_68462985 105.158 CCNB1
cyclin B1
chr14_+_58711599 104.525 PSMA3
proteasome (prosome, macropain) subunit, alpha type, 3
chr2_-_61765394 103.742 NM_003400
XPO1
exportin 1 (CRM1 homolog, yeast)
chr1_+_154947166 103.633 CKS1B
CDC28 protein kinase regulatory subunit 1B
chr5_+_177631533 102.484 HNRNPAB
heterogeneous nuclear ribonucleoprotein A/B
chr15_+_41624891 102.040 NM_001243142
NM_001243143
NM_001243144
NM_016359
NM_018454
NUSAP1




nucleolar and spindle associated protein 1




chr1_+_154947147 101.303 CKS1B
CDC28 protein kinase regulatory subunit 1B
chr17_-_79818370 101.084 P4HB
prolyl 4-hydroxylase, beta polypeptide
chr17_+_26646120 100.517 NM_014573
TMEM97
transmembrane protein 97
chr11_+_63953630 99.793 STIP1
stress-induced-phosphoprotein 1
chr14_+_58711555 98.461 PSMA3
proteasome (prosome, macropain) subunit, alpha type, 3
chr19_-_55918980 98.375 UBE2S
ubiquitin-conjugating enzyme E2S
chr1_+_154947116 95.497 NM_001826
CKS1B
CDC28 protein kinase regulatory subunit 1B
chr5_+_177631534 95.346 HNRNPAB
heterogeneous nuclear ribonucleoprotein A/B
chr17_-_79818318 93.701 P4HB
prolyl 4-hydroxylase, beta polypeptide
chr1_+_43148096 92.860 YBX1
Y box binding protein 1
chr17_-_76183074 92.331 NM_003258
TK1
thymidine kinase 1, soluble
chr15_+_41625052 91.794 NUSAP1
nucleolar and spindle associated protein 1
chr20_+_30326903 91.317 NM_012112
TPX2
TPX2, microtubule-associated, homolog (Xenopus laevis)
chr10_+_62538250 89.698 CDK1
cyclin-dependent kinase 1
chr15_+_59397276 88.266 NM_004701
CCNB2
cyclin B2
chr17_+_6347733 87.047 NM_001195228
NM_019013
FAM64A

family with sequence similarity 64, member A

chr3_+_179280686 86.538 NM_004301
NM_177989
NM_178042
ACTL6A


actin-like 6A


chr17_-_79818418 86.308 P4HB
prolyl 4-hydroxylase, beta polypeptide
chr17_+_45727274 84.800 NM_002265
KPNB1
karyopherin (importin) beta 1
chr1_+_110881944 84.424 NM_001201545
NM_022768
RBM15

RNA binding motif protein 15

chr1_+_43824598 83.822 NM_001255
CDC20
cell division cycle 20 homolog (S. cerevisiae)
chr1_-_28241233 83.616 NM_002946
RPA2
replication protein A2, 32kDa
chr1_-_225615787 83.556 NM_002296
LBR
lamin B receptor
chr9_-_128003634 83.229 NM_005347
HSPA5
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
chr10_+_62538088 81.118 NM_001170406
NM_001170407
NM_001786
NM_033379
CDK1



cyclin-dependent kinase 1



chr14_+_58711457 81.118 NM_002788
NM_152132
PSMA3

proteasome (prosome, macropain) subunit, alpha type, 3

chr10_+_124913884 80.489 BUB3
budding uninhibited by benzimidazoles 3 homolog (yeast)
chr1_+_110882063 79.930 RBM15
RNA binding motif protein 15
chr12_+_56211862 79.782 ORMDL2
ORM1-like 2 (S. cerevisiae)
chr1_-_153643474 79.459 NM_004515
ILF2
interleukin enhancer binding factor 2, 45kDa
chr1_-_35658731 78.796 SFPQ
splicing factor proline/glutamine-rich
chr15_+_41625152 78.527 NUSAP1
nucleolar and spindle associated protein 1
chr11_+_63953666 78.256 STIP1
stress-induced-phosphoprotein 1
chr6_+_24775154 77.766 NM_001251989
NM_001251990
NM_015895
GMNN


geminin, DNA replication inhibitor


chr9_-_95055913 76.756 IARS
isoleucyl-tRNA synthetase
chr19_-_14247400 75.870 NM_018154
ASF1B
ASF1 anti-silencing function 1 homolog B (S. cerevisiae)
chr1_+_110882057 75.713 RBM15
RNA binding motif protein 15
chr5_+_68462836 75.467 NM_031966
CCNB1
cyclin B1
chr8_+_11660272 75.257 FDFT1
farnesyl-diphosphate farnesyltransferase 1
chr5_+_145826866 75.129 NM_001040006
NM_006706
TCERG1

transcription elongation regulator 1

chr14_+_52456322 74.090 C14orf166
chromosome 14 open reading frame 166
chr1_+_43148048 73.548 NM_004559
YBX1
Y box binding protein 1
chr9_-_128003615 73.306 HSPA5
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
chr7_+_73097897 72.831 NM_001202560
NM_017528
WBSCR22

Williams Beuren syndrome chromosome region 22

chr1_-_225615701 72.027 LBR
lamin B receptor
chr19_+_41256758 71.782 NM_004596
SNRPA
small nuclear ribonucleoprotein polypeptide A
chr8_+_11660207 71.588 FDFT1
farnesyl-diphosphate farnesyltransferase 1
chr1_+_43148098 71.183 YBX1
Y box binding protein 1
chr2_+_27008912 70.855 CENPA
centromere protein A
chr9_-_95055966 70.618 NM_013417
IARS
isoleucyl-tRNA synthetase
chr15_-_64673569 70.522 NM_001029989
NM_014736
KIAA0101

KIAA0101

chr1_-_35658742 70.152 NM_005066
SFPQ
splicing factor proline/glutamine-rich
chr15_-_76603742 69.748 ETFA
electron-transfer-flavoprotein, alpha polypeptide
chr15_-_76603806 69.697 NM_000126
NM_001127716
ETFA

electron-transfer-flavoprotein, alpha polypeptide

chr2_-_61765367 67.883 XPO1
exportin 1 (CRM1 homolog, yeast)
chr19_-_8070468 67.879 NM_001419
ELAVL1
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)
chr8_+_11660179 67.629 NM_004462
FDFT1
farnesyl-diphosphate farnesyltransferase 1
chr14_-_55658205 67.603 NM_001146015
NM_014750
DLGAP5

discs, large (Drosophila) homolog-associated protein 5

chr2_-_61765345 67.419 XPO1
exportin 1 (CRM1 homolog, yeast)
chr4_-_1713914 66.766 NM_006527
SLBP
stem-loop binding protein
chr12_+_56211718 66.677 NM_014182
ORMDL2
ORM1-like 2 (S. cerevisiae)
chr15_-_76603728 66.662 ETFA
electron-transfer-flavoprotein, alpha polypeptide
chr13_-_31040035 66.461 NM_002128
HMGB1
high mobility group box 1
chr5_+_162864571 65.759 NM_004060
NM_199246
CCNG1

cyclin G1

chr15_-_76603791 65.587 ETFA
electron-transfer-flavoprotein, alpha polypeptide
chr15_-_41624760 65.499 NM_007280
OIP5
Opa interacting protein 5
chr7_+_73097930 64.218 WBSCR22
Williams Beuren syndrome chromosome region 22
chr11_+_63953586 64.118 NM_006819
STIP1
stress-induced-phosphoprotein 1
chr1_+_43148105 63.822 YBX1
Y box binding protein 1
chr21_-_40720938 63.320 HMGN1
high mobility group nucleosome binding domain 1
chr3_+_172468469 63.165 ECT2
epithelial cell transforming sequence 2 oncogene
chr17_-_79818514 63.139 NM_000918
P4HB
prolyl 4-hydroxylase, beta polypeptide
chr1_+_62902325 63.069 NM_003368
USP1
ubiquitin specific peptidase 1
chr6_+_80714321 63.056 NM_001166691
NM_003318
TTK

TTK protein kinase

chr9_-_128003348 62.441 HSPA5
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
chr9_-_95055989 62.330 NM_002161
IARS
isoleucyl-tRNA synthetase
chr9_-_95055986 62.315 IARS
isoleucyl-tRNA synthetase
chr1_-_150669499 62.091 NM_018178
GOLPH3L
golgi phosphoprotein 3-like
chr8_+_11660520 61.446 FDFT1
farnesyl-diphosphate farnesyltransferase 1
chr19_-_46195442 61.146 NM_004597
NM_177542
SNRPD2

small nuclear ribonucleoprotein D2 polypeptide 16.5kDa

chr21_-_40721010 60.904 NM_004965
HMGN1
high mobility group nucleosome binding domain 1
chr2_+_27008881 60.897 NM_001809
NM_001042426
CENPA

centromere protein A

chr1_+_155278538 60.422 NM_001135822
NM_001242824
NM_001242825
NM_002004
FDPS



farnesyl diphosphate synthase



chr7_+_6048921 60.148 AIMP2
aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
chr13_+_53029494 60.102 NM_001098525
NM_018204
CKAP2

cytoskeleton associated protein 2

chr17_+_46970128 60.024 NM_001002027
NM_005175
ATP5G1

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)

chr1_+_155278727 58.919 FDPS
farnesyl diphosphate synthase
chr13_-_31039966 58.333 HMGB1
high mobility group box 1
chr1_-_28240953 58.282 RPA2
replication protein A2, 32kDa
chrX_+_150151757 58.238 NM_005342
HMGB3
high mobility group box 3
chr17_+_1733313 58.230 RPA1
replication protein A1, 70kDa
chr2_-_96874507 58.193 STARD7
StAR-related lipid transfer (START) domain containing 7
chr14_+_39644360 57.638 NM_002687
PNN
pinin, desmosome associated protein
chr2_-_234763182 57.594 NM_018410
HJURP
Holliday junction recognition protein
chr3_+_37034983 56.433 MLH1
mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)
chr19_+_41770336 56.359 HNRNPUL1
heterogeneous nuclear ribonucleoprotein U-like 1
chr1_+_43148168 56.051 YBX1
Y box binding protein 1
chr17_+_18759611 55.568 NM_001243936
NM_001243942
PRPSAP2

phosphoribosyl pyrophosphate synthetase-associated protein 2

chr17_+_36908999 55.248 NM_002795
PSMB3
proteasome (prosome, macropain) subunit, beta type, 3
chr17_-_8113862 55.035 NM_004217
AURKB
aurora kinase B
chr5_+_159848835 54.702 NM_004219
PTTG1
pituitary tumor-transforming 1
chr1_+_155278677 54.557 NM_001135821
FDPS
farnesyl diphosphate synthase
chr2_-_234763145 54.393 HJURP
Holliday junction recognition protein
chr16_-_84651639 53.997 NM_021149
COTL1
coactosin-like 1 (Dictyostelium)
chr5_+_159848876 53.713 PTTG1
pituitary tumor-transforming 1
chr1_+_181057835 53.412 IER5
immediate early response 5
chr11_-_134093869 53.310 NCAPD3
non-SMC condensin II complex, subunit D3
chr8_+_11660297 53.110 FDFT1
farnesyl-diphosphate farnesyltransferase 1
chr7_+_6048858 53.107 NM_006303
AIMP2
aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
chr3_+_51422691 53.080 NM_006010
MANF
mesencephalic astrocyte-derived neurotrophic factor
chr5_-_137878915 53.070 NM_004730
ETF1
eukaryotic translation termination factor 1
chr10_+_124913921 53.052 BUB3
budding uninhibited by benzimidazoles 3 homolog (yeast)
chr20_-_5100443 52.884 NM_182649
PCNA
proliferating cell nuclear antigen
chr19_+_41770349 52.876 HNRNPUL1
heterogeneous nuclear ribonucleoprotein U-like 1
chr19_+_45394459 52.837 NM_001128916
NM_001128917
NM_006114
TOMM40


translocase of outer mitochondrial membrane 40 homolog (yeast)


chr20_-_5107185 52.551 NM_002592
PCNA
proliferating cell nuclear antigen
chr1_+_214776494 52.067 NM_016343
CENPF
centromere protein F, 350/400kDa (mitosin)
chr19_-_2042022 51.916 MKNK2
MAP kinase interacting serine/threonine kinase 2
chrX_-_77150907 51.830 NM_032121
MAGT1
magnesium transporter 1
chr5_+_44808967 51.727 NM_016640
MRPS30
mitochondrial ribosomal protein S30
chr5_+_162887516 51.365 NM_001142556
NM_001142557
NM_012484
NM_012485
HMMR



hyaluronan-mediated motility receptor (RHAMM)



chr3_+_51422716 51.362 MANF
mesencephalic astrocyte-derived neurotrophic factor
chr5_+_151151514 51.208 G3BP1
GTPase activating protein (SH3 domain) binding protein 1
chr5_-_137878808 51.139 ETF1
eukaryotic translation termination factor 1
chr11_-_67275549 51.009 CDK2AP2
cyclin-dependent kinase 2 associated protein 2
chr1_-_35658430 50.872 SFPQ
splicing factor proline/glutamine-rich
chr14_+_52456192 50.732 NM_016039
C14orf166
chromosome 14 open reading frame 166
chr11_+_66406189 50.342 RBM4
RNA binding motif protein 4
chr17_-_79980685 50.280 NM_144998
STRA13
stimulated by retinoic acid 13 homolog (mouse)
chr19_+_41770285 49.880 HNRNPUL1
heterogeneous nuclear ribonucleoprotein U-like 1
chr7_+_6048902 49.832 AIMP2
aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
chr1_+_43148142 49.788 YBX1
Y box binding protein 1
chr11_-_64545864 49.685 SF1
splicing factor 1
chr2_+_74425689 49.498 NM_006636
MTHFD2
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
chr6_+_30688144 49.492 NM_178014
TUBB
tubulin, beta class I
chr2_-_96874569 49.251 NM_020151
STARD7
StAR-related lipid transfer (START) domain containing 7
chr18_-_45457145 49.067 SMAD2
SMAD family member 2
chr16_-_84651519 48.731 COTL1
coactosin-like 1 (Dictyostelium)
chr1_-_27816676 48.595 NM_001201404
NM_006990
WASF2

WAS protein family, member 2

chr11_+_67798077 48.384 NM_002496
NDUFS8
NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)
chr19_+_3572958 47.874 HMG20B
high mobility group 20B
chr9_-_35103089 47.520 STOML2
stomatin (EPB72)-like 2
chr17_+_66031814 47.486 NM_002266
KPNA2
karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
chr16_-_58663734 46.999 CNOT1
CCR4-NOT transcription complex, subunit 1
chr19_+_41770329 46.815 HNRNPUL1
heterogeneous nuclear ribonucleoprotein U-like 1
chr2_-_96873938 46.792 STARD7
StAR-related lipid transfer (START) domain containing 7
chr19_+_3572950 46.678 HMG20B
high mobility group 20B
chr7_-_30544324 46.311 NM_001199815
NM_001199816
NM_001199817
NM_024051
GGCT



gamma-glutamylcyclotransferase



chr10_-_58121019 46.226 NM_001005413
NM_007057
NM_032997
ZWINT


ZW10 interactor


chr1_+_43148187 46.052 YBX1
Y box binding protein 1
chr10_+_124914279 45.931 BUB3
budding uninhibited by benzimidazoles 3 homolog (yeast)
chr19_+_41770273 45.723 HNRNPUL1
heterogeneous nuclear ribonucleoprotein U-like 1
chr10_-_58121011 45.675 ZWINT
ZW10 interactor
chr16_+_103892 45.602 SNRNP25
small nuclear ribonucleoprotein 25kDa (U11/U12)
chr17_+_66031885 45.511 KPNA2
karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
chr12_+_56618104 45.412 NM_024068
OBFC2B
oligonucleotide/oligosaccharide-binding fold containing 2B
chr17_-_5322982 45.389 NM_002532
NUP88
nucleoporin 88kDa
chr9_-_35103144 45.159 NM_013442
STOML2
stomatin (EPB72)-like 2
chr19_+_3572903 45.041 NM_006339
HMG20B
high mobility group 20B
chr6_+_30688085 45.006 TUBB
tubulin, beta class I
chr17_+_1733263 44.980 NM_002945
RPA1
replication protein A1, 70kDa
chr6_-_42713837 44.812 NM_003192
TBCC
tubulin folding cofactor C
chr1_+_52195458 44.727 NM_148904
NM_148905
NM_148907
OSBPL9


oxysterol binding protein-like 9


chr11_+_17298278 43.945 NM_005013
NUCB2
nucleobindin 2
chr17_+_80416606 43.731 NARF
nuclear prelamin A recognition factor
chr21_-_34852282 43.620 NM_006134
TMEM50B
transmembrane protein 50B
chr11_-_64545933 43.616 NM_001178030
SF1
splicing factor 1
chr19_+_13049413 43.502 NM_004343
CALR
calreticulin
chr16_-_69760354 43.384 NQO1
NAD(P)H dehydrogenase, quinone 1
chr3_-_141868208 43.359 NM_001178138
NM_001178139
TFDP2

transcription factor Dp-2 (E2F dimerization partner 2)

chr1_+_52195508 43.330 OSBPL9
oxysterol binding protein-like 9
chr19_-_14247267 43.015 ASF1B
ASF1 anti-silencing function 1 homolog B (S. cerevisiae)
chr15_+_80352018 42.963 ZFAND6
zinc finger, AN1-type domain 6
chr7_-_148725731 42.529 PDIA4
protein disulfide isomerase family A, member 4
chr11_-_46867840 42.430 NM_001008938
NM_014756
CKAP5

cytoskeleton associated protein 5

chr3_+_37034840 42.148 NM_000249
MLH1
mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)
chr9_-_35103048 42.087 STOML2
stomatin (EPB72)-like 2
chr4_+_166248816 42.043 NM_001017369
NM_006745
MSMO1

methylsterol monooxygenase 1

chr20_+_25388320 42.030 NM_021067
GINS1
GINS complex subunit 1 (Psf1 homolog)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.28 2.00e-37 GO:0009987 cellular process
1.55 8.59e-37 GO:0044237 cellular metabolic process
3.41 2.27e-36 GO:0022403 cell cycle phase
3.53 3.33e-33 GO:0000278 mitotic cell cycle
3.06 6.92e-33 GO:0022402 cell cycle process
2.77 2.04e-32 GO:0007049 cell cycle
1.66 1.81e-30 GO:0044260 cellular macromolecule metabolic process
1.43 1.40e-28 GO:0008152 metabolic process
3.75 2.26e-28 GO:0000279 M phase
1.47 2.04e-27 GO:0044238 primary metabolic process
1.98 6.22e-26 GO:0090304 nucleic acid metabolic process
2.19 8.55e-26 GO:0006996 organelle organization
1.77 1.16e-25 GO:0034641 cellular nitrogen compound metabolic process
1.75 2.61e-25 GO:0006807 nitrogen compound metabolic process
1.83 6.93e-25 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
4.09 9.06e-24 GO:0000087 M phase of mitotic cell cycle
1.53 1.88e-23 GO:0043170 macromolecule metabolic process
3.65 5.46e-21 GO:0010564 regulation of cell cycle process
1.78 1.10e-20 GO:0071842 cellular component organization at cellular level
1.76 1.33e-20 GO:0071841 cellular component organization or biogenesis at cellular level
3.87 3.21e-20 GO:0000280 nuclear division
3.87 3.21e-20 GO:0007067 mitosis
3.75 2.46e-19 GO:0048285 organelle fission
2.79 1.18e-18 GO:0051276 chromosome organization
1.62 7.61e-18 GO:0016043 cellular component organization
1.74 1.11e-17 GO:0009058 biosynthetic process
3.59 1.34e-17 GO:0051325 interphase
1.60 1.37e-17 GO:0071840 cellular component organization or biogenesis
3.60 2.23e-17 GO:0051329 interphase of mitotic cell cycle
4.06 3.99e-17 GO:0071156 regulation of cell cycle arrest
2.69 4.60e-17 GO:0051726 regulation of cell cycle
3.33 1.03e-16 GO:0051301 cell division
4.07 1.65e-16 GO:0000075 cell cycle checkpoint
1.71 3.76e-15 GO:0044249 cellular biosynthetic process
2.76 4.67e-14 GO:0034621 cellular macromolecular complex subunit organization
2.28 9.75e-14 GO:0043933 macromolecular complex subunit organization
2.57 9.81e-14 GO:0006259 DNA metabolic process
2.27 1.60e-13 GO:0033554 cellular response to stress
4.29 5.44e-13 GO:0071103 DNA conformation change
4.99 9.68e-13 GO:0065004 protein-DNA complex assembly
4.86 9.70e-13 GO:0071824 protein-DNA complex subunit organization
2.96 2.05e-12 GO:0034622 cellular macromolecular complex assembly
4.52 2.14e-12 GO:0006323 DNA packaging
2.34 3.40e-12 GO:0065003 macromolecular complex assembly
1.79 5.26e-12 GO:0009059 macromolecule biosynthetic process
1.78 1.51e-11 GO:0034645 cellular macromolecule biosynthetic process
1.76 1.52e-11 GO:0016070 RNA metabolic process
4.03 6.08e-10 GO:0006333 chromatin assembly or disassembly
1.89 7.26e-10 GO:0044085 cellular component biogenesis
4.67 8.73e-10 GO:0031497 chromatin assembly
2.50 1.18e-09 GO:0006325 chromatin organization
4.76 1.25e-09 GO:0006334 nucleosome assembly
1.56 1.82e-09 GO:0044267 cellular protein metabolic process
3.92 3.20e-09 GO:0006310 DNA recombination
4.44 3.77e-09 GO:0034728 nucleosome organization
4.40 4.99e-09 GO:0007059 chromosome segregation
2.37 5.32e-09 GO:0006974 response to DNA damage stimulus
1.91 5.92e-09 GO:0022607 cellular component assembly
3.63 8.92e-09 GO:0010498 proteasomal protein catabolic process
3.63 8.92e-09 GO:0043161 proteasomal ubiquitin-dependent protein catabolic process
1.65 1.03e-08 GO:0010467 gene expression
7.16 1.13e-08 GO:0016126 sterol biosynthetic process
4.73 2.34e-08 GO:0000236 mitotic prometaphase
2.29 3.08e-08 GO:0016071 mRNA metabolic process
2.91 3.34e-08 GO:0007017 microtubule-based process
7.55 6.18e-08 GO:0006695 cholesterol biosynthetic process
2.61 9.33e-08 GO:0006281 DNA repair
2.03 1.12e-07 GO:0071844 cellular component assembly at cellular level
2.25 1.32e-07 GO:0044265 cellular macromolecule catabolic process
3.59 1.83e-07 GO:0000082 G1/S transition of mitotic cell cycle
2.81 2.06e-07 GO:0007346 regulation of mitotic cell cycle
1.75 2.21e-07 GO:0051641 cellular localization
2.13 2.37e-07 GO:0009057 macromolecule catabolic process
1.60 3.42e-07 GO:0044281 small molecule metabolic process
3.95 4.42e-07 GO:0000086 G2/M transition of mitotic cell cycle
3.19 4.82e-07 GO:0006260 DNA replication
4.45 1.42e-06 GO:0000216 M/G1 transition of mitotic cell cycle
1.74 2.45e-06 GO:0044248 cellular catabolic process
2.03 3.55e-06 GO:0006396 RNA processing
2.55 3.65e-06 GO:0008380 RNA splicing
3.53 3.73e-06 GO:0007093 mitotic cell cycle checkpoint
2.93 6.35e-06 GO:0006457 protein folding
1.46 8.66e-06 GO:0006950 response to stress
1.63 9.32e-06 GO:0009056 catabolic process
1.72 1.20e-05 GO:0051649 establishment of localization in cell
3.19 1.50e-05 GO:0000226 microtubule cytoskeleton organization
2.03 1.52e-05 GO:0071822 protein complex subunit organization
4.10 1.84e-05 GO:0007088 regulation of mitosis
4.10 1.84e-05 GO:0051783 regulation of nuclear division
5.49 2.01e-05 GO:0000819 sister chromatid segregation
3.57 2.05e-05 GO:0051320 S phase
2.82 2.95e-05 GO:0000375 RNA splicing, via transesterification reactions
2.24 4.14e-05 GO:0006091 generation of precursor metabolites and energy
3.50 6.18e-05 GO:0000084 S phase of mitotic cell cycle
1.83 7.65e-05 GO:0046907 intracellular transport
3.97 7.73e-05 GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
1.37 8.49e-05 GO:0019538 protein metabolic process
2.36 1.04e-04 GO:0006511 ubiquitin-dependent protein catabolic process
4.93 1.18e-04 GO:0007051 spindle organization
2.19 1.54e-04 GO:0006397 mRNA processing
2.30 1.62e-04 GO:0051603 proteolysis involved in cellular protein catabolic process
3.55 1.69e-04 GO:0006694 steroid biosynthetic process
2.31 1.93e-04 GO:0019941 modification-dependent protein catabolic process
2.29 2.36e-04 GO:0043632 modification-dependent macromolecule catabolic process
2.25 2.93e-04 GO:0044257 cellular protein catabolic process
2.20 3.57e-04 GO:0030163 protein catabolic process
5.16 4.31e-04 GO:0000070 mitotic sister chromatid segregation
2.65 5.29e-04 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
2.65 5.29e-04 GO:0000398 nuclear mRNA splicing, via spliceosome
3.21 6.60e-04 GO:0051640 organelle localization
1.42 9.96e-04 GO:0048523 negative regulation of cellular process
10.57 1.29e-03 GO:0000085 G2 phase of mitotic cell cycle
10.57 1.29e-03 GO:0051319 G2 phase
3.19 1.31e-03 GO:0007126 meiosis
3.19 1.31e-03 GO:0051327 M phase of meiotic cell cycle
1.96 1.51e-03 GO:0070271 protein complex biogenesis
3.16 1.56e-03 GO:0051321 meiotic cell cycle
5.93 1.78e-03 GO:0006271 DNA strand elongation involved in DNA replication
1.98 1.90e-03 GO:0006066 alcohol metabolic process
2.00 1.99e-03 GO:0044262 cellular carbohydrate metabolic process
3.02 2.11e-03 GO:0010639 negative regulation of organelle organization
1.94 2.66e-03 GO:0006461 protein complex assembly
3.50 2.82e-03 GO:0051656 establishment of organelle localization
1.37 3.21e-03 GO:0048522 positive regulation of cellular process
5.54 4.02e-03 GO:0022616 DNA strand elongation
1.42 4.04e-03 GO:0043412 macromolecule modification
3.17 4.39e-03 GO:0016125 sterol metabolic process
1.79 5.05e-03 GO:0005975 carbohydrate metabolic process
3.21 6.20e-03 GO:0051340 regulation of ligase activity
1.89 6.63e-03 GO:0007010 cytoskeleton organization
1.17 7.16e-03 GO:0050794 regulation of cellular process
2.74 8.43e-03 GO:0051052 regulation of DNA metabolic process
2.10 8.79e-03 GO:0033043 regulation of organelle organization
1.36 9.19e-03 GO:0048519 negative regulation of biological process
2.94 9.49e-03 GO:0031570 DNA integrity checkpoint
1.15 9.63e-03 GO:0065007 biological regulation
3.66 1.04e-02 GO:0010948 negative regulation of cell cycle process
1.41 1.04e-02 GO:0006464 protein modification process
2.02 1.11e-02 GO:0016568 chromatin modification
5.04 1.18e-02 GO:0051297 centrosome organization
3.32 1.22e-02 GO:0051351 positive regulation of ligase activity
3.19 1.24e-02 GO:0051438 regulation of ubiquitin-protein ligase activity
4.27 1.32e-02 GO:0006458 'de novo' protein folding
1.59 1.34e-02 GO:0032774 RNA biosynthetic process
1.27 1.34e-02 GO:0080090 regulation of primary metabolic process
2.18 1.35e-02 GO:0015980 energy derivation by oxidation of organic compounds
10.07 1.38e-02 GO:0002566 somatic diversification of immune receptors via somatic mutation
10.07 1.38e-02 GO:0016446 somatic hypermutation of immunoglobulin genes
1.27 1.43e-02 GO:0031323 regulation of cellular metabolic process
1.55 1.60e-02 GO:0008104 protein localization
1.25 1.75e-02 GO:0019222 regulation of metabolic process
1.56 1.81e-02 GO:0032268 regulation of cellular protein metabolic process
1.55 1.84e-02 GO:0010941 regulation of cell death
1.56 1.96e-02 GO:0042981 regulation of apoptosis
3.34 2.04e-02 GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
2.74 2.06e-02 GO:0046034 ATP metabolic process
1.28 2.06e-02 GO:0060255 regulation of macromolecule metabolic process
1.15 2.07e-02 GO:0050789 regulation of biological process
3.29 2.46e-02 GO:0051443 positive regulation of ubiquitin-protein ligase activity
3.16 2.47e-02 GO:0018196 peptidyl-asparagine modification
3.16 2.47e-02 GO:0018279 protein N-linked glycosylation via asparagine
1.87 2.56e-02 GO:0008283 cell proliferation
1.53 2.68e-02 GO:0051246 regulation of protein metabolic process
1.59 2.75e-02 GO:0055114 oxidation-reduction process
1.54 2.78e-02 GO:0043067 regulation of programmed cell death
1.50 2.83e-02 GO:0050790 regulation of catalytic activity
5.04 3.20e-02 GO:0071174 mitotic cell cycle spindle checkpoint
3.71 3.47e-02 GO:0000910 cytokinesis
1.47 3.60e-02 GO:0033036 macromolecule localization
2.88 3.62e-02 GO:0090068 positive regulation of cell cycle process
4.49 4.09e-02 GO:0031023 microtubule organizing center organization
2.85 4.19e-02 GO:0000077 DNA damage checkpoint
5.44 4.28e-02 GO:0002200 somatic diversification of immune receptors
1.30 4.54e-02 GO:0048518 positive regulation of biological process
2.82 4.83e-02 GO:0042770 signal transduction in response to DNA damage

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.35 8.51e-66 GO:0044424 intracellular part
1.32 9.25e-62 GO:0005622 intracellular
1.42 4.43e-59 GO:0043226 organelle
1.42 4.81e-59 GO:0043229 intracellular organelle
1.47 1.17e-58 GO:0043227 membrane-bounded organelle
1.47 5.61e-58 GO:0043231 intracellular membrane-bounded organelle
1.72 4.67e-56 GO:0044422 organelle part
1.73 7.15e-56 GO:0044446 intracellular organelle part
1.42 3.22e-40 GO:0005737 cytoplasm
1.60 1.24e-37 GO:0005634 nucleus
1.81 2.56e-35 GO:0032991 macromolecular complex
2.02 1.10e-30 GO:0070013 intracellular organelle lumen
1.99 2.58e-30 GO:0031974 membrane-enclosed lumen
2.02 1.66e-29 GO:0044428 nuclear part
1.98 3.75e-29 GO:0043233 organelle lumen
1.49 7.01e-29 GO:0044444 cytoplasmic part
3.20 2.42e-26 GO:0005694 chromosome
1.99 1.56e-22 GO:0031981 nuclear lumen
1.75 8.77e-22 GO:0043228 non-membrane-bounded organelle
1.75 8.77e-22 GO:0043232 intracellular non-membrane-bounded organelle
3.17 3.90e-21 GO:0044427 chromosomal part
1.70 4.60e-21 GO:0043234 protein complex
1.84 1.95e-19 GO:0005829 cytosol
2.07 6.44e-18 GO:0005654 nucleoplasm
1.09 1.35e-14 GO:0044464 cell part
1.09 1.42e-14 GO:0005623 cell
2.38 9.73e-14 GO:0015630 microtubule cytoskeleton
2.22 1.81e-11 GO:0031967 organelle envelope
2.18 5.56e-11 GO:0031975 envelope
3.55 1.34e-10 GO:0005819 spindle
3.15 2.95e-10 GO:0000785 chromatin
3.80 1.45e-09 GO:0000793 condensed chromosome
3.47 2.00e-09 GO:0044454 nuclear chromosome part
2.32 2.29e-09 GO:0030529 ribonucleoprotein complex
3.17 2.35e-09 GO:0000228 nuclear chromosome
2.11 4.11e-09 GO:0044429 mitochondrial part
4.29 2.14e-08 GO:0032993 protein-DNA complex
3.51 6.10e-08 GO:0000775 chromosome, centromeric region
1.69 1.21e-07 GO:0005739 mitochondrion
2.20 7.91e-07 GO:0005740 mitochondrial envelope
1.50 8.40e-07 GO:0031090 organelle membrane
4.78 2.13e-06 GO:0000786 nucleosome
3.95 3.42e-06 GO:0000776 kinetochore
3.92 3.60e-05 GO:0000779 condensed chromosome, centromeric region
1.65 4.46e-05 GO:0044430 cytoskeletal part
2.55 4.99e-05 GO:0005813 centrosome
3.99 5.74e-05 GO:0000777 condensed chromosome kinetochore
2.33 7.25e-05 GO:0005874 microtubule
2.05 7.68e-05 GO:0031966 mitochondrial membrane
1.78 1.14e-04 GO:0044451 nucleoplasm part
1.74 2.35e-04 GO:0044432 endoplasmic reticulum part
1.47 3.79e-04 GO:0012505 endomembrane system
2.10 7.50e-04 GO:0005815 microtubule organizing center
4.12 7.57e-04 GO:0000794 condensed nuclear chromosome
2.09 8.16e-04 GO:0019866 organelle inner membrane
1.46 9.98e-04 GO:0005856 cytoskeleton
2.24 1.39e-03 GO:0005759 mitochondrial matrix
3.66 1.88e-03 GO:0000922 spindle pole
3.84 1.98e-03 GO:0030496 midbody
2.08 2.71e-03 GO:0005743 mitochondrial inner membrane
6.71 3.67e-03 GO:0030530 heterogeneous nuclear ribonucleoprotein complex
2.19 5.65e-03 GO:0005635 nuclear envelope
3.06 7.38e-03 GO:0042470 melanosome
3.06 7.38e-03 GO:0048770 pigment granule
1.65 7.72e-03 GO:0042175 nuclear membrane-endoplasmic reticulum network
2.90 9.51e-03 GO:0005788 endoplasmic reticulum lumen
1.64 1.20e-02 GO:0005789 endoplasmic reticulum membrane
8.24 1.22e-02 GO:0000780 condensed nuclear chromosome, centromeric region
1.48 1.61e-02 GO:0005783 endoplasmic reticulum
9.44 2.54e-02 GO:0042555 MCM complex
1.71 3.33e-02 GO:0005730 nucleolus
2.07 4.96e-02 GO:0016604 nuclear body

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.45 8.02e-34 GO:0005515 protein binding
1.20 4.59e-23 GO:0005488 binding
1.92 1.03e-07 GO:0003723 RNA binding
1.38 9.07e-07 GO:0003676 nucleic acid binding
1.23 7.54e-05 GO:0003824 catalytic activity
1.41 8.75e-05 GO:0000166 nucleotide binding
1.77 1.24e-04 GO:0019899 enzyme binding
4.24 3.11e-04 GO:0003697 single-stranded DNA binding
2.53 8.69e-04 GO:0043566 structure-specific DNA binding
1.67 1.26e-03 GO:0016817 hydrolase activity, acting on acid anhydrides
2.83 1.77e-03 GO:0016853 isomerase activity
1.45 1.82e-03 GO:0030554 adenyl nucleotide binding
1.66 2.00e-03 GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
1.45 2.46e-03 GO:0005524 ATP binding
2.44 2.85e-03 GO:0003682 chromatin binding
1.65 3.14e-03 GO:0016462 pyrophosphatase activity
1.44 3.45e-03 GO:0032559 adenyl ribonucleotide binding
2.69 4.63e-03 GO:0003690 double-stranded DNA binding
1.65 4.83e-03 GO:0017111 nucleoside-triphosphatase activity
1.33 9.63e-03 GO:0003677 DNA binding
4.15 2.32e-02 GO:0003678 DNA helicase activity
3.36 2.93e-02 GO:0008094 DNA-dependent ATPase activity
1.89 3.02e-02 GO:0016887 ATPase activity
1.33 4.14e-02 GO:0017076 purine nucleotide binding
1.34 4.24e-02 GO:0035639 purine ribonucleoside triphosphate binding
3.86 4.81e-02 GO:0042826 histone deacetylase binding